Pharmacogenomics of insulin like growth factor I generation during GH treatment in children with GH deficiency or Turner syndrome The Pharmacogenomics Journal How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Interrelationship between growth hormone (GH), insulin like growth Download Scientific Diagram Everyone's calling GHK Cu a miracle peptide But let's separate marketing from mechanism. GHK Cu isn't magic. It's a signal. A signal that: Supports tissue repair Modulates inflammation Enhances collagen + The GH IGF 1 axis in obesity: pathophysiology and therapeutic considerations Nature Reviews Endocrinology